Wednesday, June 23, 2010

Microwells to detect odors.

news
United States scientists have developed a microfluidic-based platform that filters out hundreds of cells at a time and can be used to identify the behavior of cells that are rare in helping to stem cell research and cancer biology, they claim.

Ten of the hundreds of odorant molecules can be distinguished by the nose. Olfactory sensory neurons (OSNs) in the nasal odorant chemical signals translate into a unique neuronal signals which guide the behavior of many important. Odours activate odorant receptors (ORS) in which there are over 1000 types in mice. Each OSN showed only or in the type of OR, but due to large amounts is not possible to analyze the response during all types of odour-OR OSN using current techniques.

Albert Folch now at the University of Washington, Seattle and his team have developed a method to filter out nearly 20 000 single cells at a time on the unity of microwell. By using calcium imaging they were able to detect and analyze a number of odorant responses of rat OSNs simultaneously, clearly Folch, by enabling the cells with a rare pattern of responses found.

Folch compare several responses OSN with four odors of different fruits (vanilla, roses, berries and bananas) in one experiment. By using calcium imaging, the response of neurons identified by measuring changes in fluorescence signal. Folch explains that by using microwell to be placed on hundreds of OSNs in the camera visibility means that all the ORS should be represented in the sample. 'I believe that these microarrays are very powerful at finding the rare cells showing a particular pattern of response of which is not likely to be found with any reason' he said.

Tim Holy, who examined the olfactory system in rats at Washington University in St. Louis, United States, saying that 'This is an elegant new approach to record many neurons simultaneously maintained under stimulus conditions very well. "

Folch said that his team would eventually develop a system whereby cells are exposed to some odour in the gas phase, 'I expect, but can not prove, that the various problems with OSN survival and artifacts pembauan / adaptation comes from the fact bahwasannya odorant ( most of them dissolved in the water) just as if 'he added.

news
United States scientists have developed a microfluidic-based platform that filters out hundreds of cells at a time and can be used to identify the behavior of cells that are rare in helping to stem cell research and cancer biology, they claim.

Ten of the hundreds of odorant molecules can be distinguished by the nose. Olfactory sensory neurons (OSNs) in the nasal odorant chemical signals translate into a unique neuronal signals which guide the behavior of many important. Odours activate odorant receptors (ORS) in which there are over 1000 types in mice. Each OSN showed only or in the type of OR, but due to large amounts is not possible to analyze the response during all types of odour-OR OSN using current techniques.

Albert Folch now at the University of Washington, Seattle and his team have developed a method to filter out nearly 20 000 single cells at a time on the unity of microwell. By using calcium imaging they were able to detect and analyze a number of odorant responses of rat OSNs simultaneously, clearly Folch, by enabling the cells with a rare pattern of responses found.

Folch compare several responses OSN with four odors of different fruits (vanilla, roses, berries and bananas) in one experiment. By using calcium imaging, the response of neurons identified by measuring changes in fluorescence signal. Folch explains that by using microwell to be placed on hundreds of OSNs in the camera visibility means that all the ORS should be represented in the sample. 'I believe that these microarrays are very powerful at finding the rare cells showing a particular pattern of response of which is not likely to be found with any reason' he said.

Tim Holy, who examined the olfactory system in rats at Washington University in St. Louis, United States, saying that 'This is an elegant new approach to record many neurons simultaneously maintained under stimulus conditions very well. "

Folch said that his team would eventually develop a system whereby cells are exposed to some odour in the gas phase, 'I expect, but can not prove, that the various problems with OSN survival and artifacts pembauan / adaptation comes from the fact bahwasannya odorant ( most of them dissolved in the water) just as if 'he added.

11 comments :

  1. 涂宛臻 said...

    Poverty is stranger to industry..................................................................                           

  2. 文辰文辰 said...

    知識可以傳授,智慧卻不行。每個人必須成為他自己。......................................................................

  3. 凱文凱文 said...

    當一個人內心能容納兩樣相互衝突的東西,這個人便開始變得有價值了。............................................................

  4. 王名仁 said...

    人生是故事的創造與遺忘。............................................................

  5. JasonBirk佳琪 said...

    當一個人內心能容納兩樣相互衝突的東西,這個人便開始變得有價值了。............................................................

  6. 宥妃宥妃 said...

    人生的苦惱,不在擁有太少,而在奢望太多。..................................................

  7. 原秋原秋 said...

    文章雖然普通,但意義卻很大~~^^~~ ..................................................................

  8. 嘉雯 said...

    感謝您願意分享您的生活經驗~~支持您的更新哦!............................................................

  9. 俊成俊成 said...

    要持續更新下去喲!!祝你有個愉快心情..................................................................

  10. 原秋原秋 said...

    Failure is the mother of success...................................................

  11. 陳韋夏陳韋夏益東富益東富 said...

    生命如夏花洵爛;死如秋葉之靜美。.......................................................

Post a Comment

you give times, i give you world,
if you have a website or something, please at the contents. thanks..

best regards,