Sunday, July 25, 2010

Unity accelerate neuron toxicity testing.

Scientists in Germany have developed an alternative to animal testing of rapid screening and identification of chemical substances that contain a health risk to the nervous system. Several laboratories worldwide neurotoksinitas facing daunting challenges in screening chemicals for catalog growth for whatever identify risks to human health, with the introduction of legislation mnegacu - invitation of the EU's Reach. Toxicity testing has been done traditionally by using animals but with the cost overruns in relation to the funds and the number of animals, salinity penggujian reliable in vitro is needed. Lack of comparable readings between in vivo and in vitro systems can mnyajikan suaatu problems, said Jonathan West at the University of Dortmund, Germany, but West said he had to settle these problems by using neural network.

This new testing platform, called the network formation assay (NFA), to monitor the connection (or developments) specifically between neurons - the neurons are placed and their neighbors. Formation of some of these connections is one of the basic principles in memory and learning, and gangguannnya is often the clinical signs neurotoksinitas, said West. 'Because the NFA test the connections of neurons then presents a model in vitro are comparable with the situation in vivo', he added.

West put the neurons - in the composition of human neurons segilima using patterns of cells - the cells and subsequent formation easier to monitor its network. Composition becomes acrylamida exposure, a neurotoxin that blocks the reference compounds and network formation to distinguish between the effects of neurotoxins with cytiotoksin. Without the need to place neurons - neurons or measure the length of connections, this means that a typical arrangement should only take three hours compared with more than 200 hours in testing manually.

'Application of simple and sophisticated micro system - this engineering can significantly improve the standard biological protocol', says Marco Cecchini, an expert on high-level resolution pemolaan biomaterials, the National Enterprise for nanoscience and nanotechnology, Pisa, Italy.

'NFA will also be applied in the context of reproductive testing of toxin levels are expected mngkonsumsi approximately 60% of all animals required for Reach and further areas most needed for the new assay in vitro' add Marcel Leist, University of Konstanz, Germany , who worked on this project together with the West.

Today, the team is working with teams throughout Europe to adopt the NFA in use with a network of neuron cells but 'real acid test will digunakankah NFA or not adopted by the laboratory neurotoksikologi and accepted by the authorities,' said West.

Scientists in Germany have developed an alternative to animal testing of rapid screening and identification of chemical substances that contain a health risk to the nervous system. Several laboratories worldwide neurotoksinitas facing daunting challenges in screening chemicals for catalog growth for whatever identify risks to human health, with the introduction of legislation mnegacu - invitation of the EU's Reach. Toxicity testing has been done traditionally by using animals but with the cost overruns in relation to the funds and the number of animals, salinity penggujian reliable in vitro is needed. Lack of comparable readings between in vivo and in vitro systems can mnyajikan suaatu problems, said Jonathan West at the University of Dortmund, Germany, but West said he had to settle these problems by using neural network.

This new testing platform, called the network formation assay (NFA), to monitor the connection (or developments) specifically between neurons - the neurons are placed and their neighbors. Formation of some of these connections is one of the basic principles in memory and learning, and gangguannnya is often the clinical signs neurotoksinitas, said West. 'Because the NFA test the connections of neurons then presents a model in vitro are comparable with the situation in vivo', he added.

West put the neurons - in the composition of human neurons segilima using patterns of cells - the cells and subsequent formation easier to monitor its network. Composition becomes acrylamida exposure, a neurotoxin that blocks the reference compounds and network formation to distinguish between the effects of neurotoxins with cytiotoksin. Without the need to place neurons - neurons or measure the length of connections, this means that a typical arrangement should only take three hours compared with more than 200 hours in testing manually.

'Application of simple and sophisticated micro system - this engineering can significantly improve the standard biological protocol', says Marco Cecchini, an expert on high-level resolution pemolaan biomaterials, the National Enterprise for nanoscience and nanotechnology, Pisa, Italy.

'NFA will also be applied in the context of reproductive testing of toxin levels are expected mngkonsumsi approximately 60% of all animals required for Reach and further areas most needed for the new assay in vitro' add Marcel Leist, University of Konstanz, Germany , who worked on this project together with the West.

Today, the team is working with teams throughout Europe to adopt the NFA in use with a network of neuron cells but 'real acid test will digunakankah NFA or not adopted by the laboratory neurotoksikologi and accepted by the authorities,' said West.

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