Monday, March 1, 2010

Nano particles

Nano particles are not toxic and can be kicked Movement Taking Drugs.

A non-toxic nano particles, developed by Penn State researchers have proved an effective transportation system for therapeutic drugs or dyes that can fluorosens track pengantarannya process.

In the latest online edition of Nano Letters, a group of scientists from the fields of materials science and engineering, chemistry, biotechnology, physics, and pharmaceuticals showed that calcium phosphate particles with a size of 20 to 50 nanometers can enter the cell and loose with safety, the burden is taken off in the form drugs or dyes.

Peter Butler, a candidate in the field of biotechnology professor and his students use a high-speed lasers to measure the particle size containing dyes fluorosen of difusinya in solution.

"We use a technique called single photon measurement with correlation time", said Butler. "This technique uses a laser wave in the measuring time, the size of nano seconds, for molecules ray casting."

With this method, the group succeeded in measuring the size of the particles and in solution dispersinya, in this case a standard saline solution containing phosphate which is used as a simple model for the blood.

"What we are doing in this research is to change the neutral pH of the solution, which resembles the blood, becoming more acidic, such as those found around the tumor and in the parts of the collected cells containing nano particles of fluid outside the cell membrane and carried into the cells. When we lower the pH, the acid environment of calcium phosphate particles dissolve, "he added.

"Can we observe that the particle size becomes very small, until the size of free dye in the particle. This provides evidence that changes in pH can be used as a mechanism to release the drug contained in particles, "explained Butler.

Although the primary use of these particles is intended to treat cancer, Butler groups interested precisely in its ability to deliver various types of drugs shown to inhibit cell growth that can cause blood vessel disease.

Some drugs used in the culture appear promising in reducing hardening of the arteries and narrowing of blood vessels after balloon angioplasty. Butler said that the problem is how to bring these drugs to the target.

Ceramide, a molecule that triggers the chemotherapy of cancer cell death, also have the ability to reduce the growth of cells healthy.

Mark Kester, a professor of pharmacy, and Jong Yun, professor of pharmaceutical candidates, both from Penn State Faculty of Pharmacy, has been optimizing Ceramide good for cancer or blood vessel disease.

Groups they found that by using human muscle smooth vessels in vitro, which dikapsul Ceramide in calcium phosphate nano particles can reduce muscle cell growth by 80% with the number 25 times less than Ceramide is used freely, without causing damage to the cells.

Calcium phosphate nano particles was developed by James Adair, professor of materials science and engineering, and his students. Nano particles has several advantages that are not owned by any other drug transport systems, according to author Thomas Morgan, a graduate student in chemistry.

Unlike quantum dots, which are composed of toxic metals, mineral calcium phosphate is a safe natural nature, which has been present in large amounts in the blood.

"What distinguishes the method we use (by other methods - ed) is (we use) the particles are smaller (to be taken into the cell), does not occur agglomeration (particle dispersed evenly in solution), and we kept the drug - drugs or dye in the particles, rather than on the surface, "said Morgan. "For reasons we do not know, fluorens dyes wrapped in our nano particles four times brighter than the free dye."

"Drugs and the dye is very expensive," he continued, "but the benefits of pengapsulan is the amount (of drugs and dyes) that needed a little more. We can make it in high concentrations in the laboratory, and mengencerkannya and still remain effective. We even believe we can combine the delivery of drugs and pigments for penjejakan and treatment simultaneously. It is one thing that currently we're doing. "

Other researchers on this project is Erhan Altinoglu and Tabakovic Amra, a graduate student in engineering materials, and a former member, Sara Rouse, doctorate in materials; postgraduate students of biotechnology, and Tristan Muddana Day Tabouillot; physicist Timothy Russin; farmakator Sriram Shanmugavelandy; and Peter Eklund, distinguished professor of physics and materials science.

Nano particles are not toxic and can be kicked Movement Taking Drugs.

A non-toxic nano particles, developed by Penn State researchers have proved an effective transportation system for therapeutic drugs or dyes that can fluorosens track pengantarannya process.

In the latest online edition of Nano Letters, a group of scientists from the fields of materials science and engineering, chemistry, biotechnology, physics, and pharmaceuticals showed that calcium phosphate particles with a size of 20 to 50 nanometers can enter the cell and loose with safety, the burden is taken off in the form drugs or dyes.

Peter Butler, a candidate in the field of biotechnology professor and his students use a high-speed lasers to measure the particle size containing dyes fluorosen of difusinya in solution.

"We use a technique called single photon measurement with correlation time", said Butler. "This technique uses a laser wave in the measuring time, the size of nano seconds, for molecules ray casting."

With this method, the group succeeded in measuring the size of the particles and in solution dispersinya, in this case a standard saline solution containing phosphate which is used as a simple model for the blood.

"What we are doing in this research is to change the neutral pH of the solution, which resembles the blood, becoming more acidic, such as those found around the tumor and in the parts of the collected cells containing nano particles of fluid outside the cell membrane and carried into the cells. When we lower the pH, the acid environment of calcium phosphate particles dissolve, "he added.

"Can we observe that the particle size becomes very small, until the size of free dye in the particle. This provides evidence that changes in pH can be used as a mechanism to release the drug contained in particles, "explained Butler.

Although the primary use of these particles is intended to treat cancer, Butler groups interested precisely in its ability to deliver various types of drugs shown to inhibit cell growth that can cause blood vessel disease.

Some drugs used in the culture appear promising in reducing hardening of the arteries and narrowing of blood vessels after balloon angioplasty. Butler said that the problem is how to bring these drugs to the target.

Ceramide, a molecule that triggers the chemotherapy of cancer cell death, also have the ability to reduce the growth of cells healthy.

Mark Kester, a professor of pharmacy, and Jong Yun, professor of pharmaceutical candidates, both from Penn State Faculty of Pharmacy, has been optimizing Ceramide good for cancer or blood vessel disease.

Groups they found that by using human muscle smooth vessels in vitro, which dikapsul Ceramide in calcium phosphate nano particles can reduce muscle cell growth by 80% with the number 25 times less than Ceramide is used freely, without causing damage to the cells.

Calcium phosphate nano particles was developed by James Adair, professor of materials science and engineering, and his students. Nano particles has several advantages that are not owned by any other drug transport systems, according to author Thomas Morgan, a graduate student in chemistry.

Unlike quantum dots, which are composed of toxic metals, mineral calcium phosphate is a safe natural nature, which has been present in large amounts in the blood.

"What distinguishes the method we use (by other methods - ed) is (we use) the particles are smaller (to be taken into the cell), does not occur agglomeration (particle dispersed evenly in solution), and we kept the drug - drugs or dye in the particles, rather than on the surface, "said Morgan. "For reasons we do not know, fluorens dyes wrapped in our nano particles four times brighter than the free dye."

"Drugs and the dye is very expensive," he continued, "but the benefits of pengapsulan is the amount (of drugs and dyes) that needed a little more. We can make it in high concentrations in the laboratory, and mengencerkannya and still remain effective. We even believe we can combine the delivery of drugs and pigments for penjejakan and treatment simultaneously. It is one thing that currently we're doing. "

Other researchers on this project is Erhan Altinoglu and Tabakovic Amra, a graduate student in engineering materials, and a former member, Sara Rouse, doctorate in materials; postgraduate students of biotechnology, and Tristan Muddana Day Tabouillot; physicist Timothy Russin; farmakator Sriram Shanmugavelandy; and Peter Eklund, distinguished professor of physics and materials science.

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